Melamed 1994.

Methods	Parallel‐group RCT
Participants	86 participants with seasonal allergic conjunctivitis
Interventions	Two treatment arms: nedocromil sodium; placebo. Duration of treatment 8 weeks
Outcomes	Participants' assessment of symptoms ‐‐ sum score itching, burning, tearing, overall eye condition Clinicians' assessment of ocular signs and symptoms (using a scale 0 = none, 4 = very severe) Time points: at baseline and peak pollen period during the 8 weeks of treatment
Country	United States
Number randomised, gender (male:female)	86 participants randomised, 85 participants analysed. M:F 49:36
Age mean (SD), median, range	Mean (range) nedocromil sodium 33.1 years (13‐60); placebo 31.1 years (13‐57)
Notes	Not reported when study was conducted. Source of funding: support in part by Fisons Pharmaceuticals. Declaration of interest by the authors was not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The method used to generate the allocation sequence was not described
Allocation concealment (selection bias)	Unclear risk	The method used to conceal the allocation sequence was not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data were nearly fully reported, with less than 10% lost to follow‐up, and reasons were given
Selective reporting (reporting bias)	Low risk	Evidence was available of proper outcome reporting
Other bias	Low risk	No apparent evidence of other risk of bias
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐masked and identical package (p.58 ‐ study design): "The study was designed as a multicenter, randomized, double‐masked... Active and placebo drugs were packaged identically and labeled in opaque polyethylene bottles..."
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐masked and identical package (p. 58 ‐ study design): "The study was designed as a multicenter, randomized, double‐masked... Active and placebo drugs were packaged identically and labeled in opaque polyethylene bottles..."