Table 2.
Heterogenity and pleiotropy analyses of circulating cytokines on sepsis.
| Heterogenity | MR-Egger intercept | ||||
|---|---|---|---|---|---|
| Q | Q_P -value | Egger_intercept | SE | P -value | |
| CTACK levels | 10.741 | 0.465 | 0.007 | 0.014 | 0.638 |
| beta-nerve growth factor levels | 4.776 | 0.687 | -0.014 | 0.032 | 0.681 |
| Vascular endothelial growth factor levels | 7.061 | 0.631 | -0.021 | 0.020 | 0.319 |
| Macrophage Migration Inhibitory Factor levels | 4.582 | 0.801 | 0.017 | 0.016 | 0.342 |
| TRAIL levels | 18.536 | 0.293 | -0.004 | 0.009 | 0.691 |
| Tumor necrosis factor beta levels | 4.239 | 0.237 | 0.018 | 0.014 | 0.322 |
| Tumor necrosis factor alpha levels | 5.675 | 0.225 | -0.027 | 0.015 | 0.178 |
| Stromal-cell-derived factor 1 alpha levels | 9.083 | 0.335 | 0.002 | 0.012 | 0.851 |
| Stem cell growth factor beta levels | 18.002 | 0.207 | -0.003 | 0.011 | 0.766 |
| Stem cell factor levels | 15.325 | 0.121 | -0.013 | 0.016 | 0.432 |
| Interleukin-16 levels | 6.444 | 0.598 | 0.013 | 0.015 | 0.410 |
| RANTES levels | 4.965 | 0.664 | 0.012 | 0.021 | 0.584 |
| Platelet-derived growth factor BB levels | 17.646 | 0.171 | -0.013 | 0.011 | 0.268 |
| Macrophage inflammatory protein 1b levels | 12.883 | 0.845 | 0.004 | 0.008 | 0.649 |
| Macrophage inflammatory protein 1a levels | 2.804 | 0.833 | 0.020 | 0.021 | 0.391 |
| Monokine induced by gamma interferon levels | 15.453 | 0.280 | 0.010 | 0.015 | 0.516 |
| Macrophage colony stimulating factor levels | 4.539 | 0.806 | -0.009 | 0.017 | 0.612 |
| Monocyte chemoattractant protein-3 levels | 0.914 | 0.822 | -0.003 | 0.029 | 0.932 |
| Monocyte chemoattractant protein-1 levels | 11.304 | 0.662 | -0.013 | 0.010 | 0.232 |
| Interleukin-12p70 levels | 19.607 | 0.105 | -0.008 | 0.010 | 0.401 |
| Interferon gamma-induced protein 10 levels | 6.051 | 0.642 | -0.012 | 0.013 | 0.394 |
| Interleukin-18 levels | 11.363 | 0.878 | 0.002 | 0.009 | 0.860 |
| Interleukin-17 levels | 18.474 | 0.071 | 0.030 | 0.018 | 0.125 |
| Interleukin-13 levels | 8.215 | 0.314 | -0.014 | 0.017 | 0.434 |
| Interleukin-10 levels | 15.142 | 0.127 | -0.014 | 0.012 | 0.252 |
| Interleukin-8 levels | 1.225 | 0.747 | 0.001 | 0.014 | 0.960 |
| Interleukin-6 levels | 6.024 | 0.537 | -0.015 | 0.014 | 0.323 |
| Interleukin-1-receptor antagonist levels | 6.355 | 0.608 | 0.017 | 0.017 | 0.338 |
| Interleukin-1-beta levels | 1.192 | 0.879 | -0.020 | 0.019 | 0.371 |
| Hepatocyte growth factor levels | 16.328 | 0.022 | -0.029 | 0.028 | 0.338 |
| Interleukin-9 levels | 11.663 | 0.070 | 0.019 | 0.029 | 0.552 |
| Interleukin-7 levels | 6.919 | 0.806 | -0.010 | 0.016 | 0.538 |
| Interleukin-5 levels | 4.865 | 0.301 | -0.017 | 0.025 | 0.540 |
| Interleukin-4 levels | 8.296 | 0.600 | 0.012 | 0.011 | 0.311 |
| Interleukin-2 receptor antagonist levels | 1.875 | 0.966 | -0.001 | 0.012 | 0.951 |
| Interleukin-2 levels | 9.779 | 0.369 | 0.007 | 0.012 | 0.557 |
| Interferon gamma levels | 13.637 | 0.325 | 0.014 | 0.012 | 0.275 |
| Growth-regulated protein alpha levels | 13.213 | 0.105 | 0.010 | 0.022 | 0.672 |
| Granulocyte-colony stimulating factor levels | 8.435 | 0.392 | -0.017 | 0.011 | 0.162 |
| Fibroblast growth factor basic levels | 4.850 | 0.678 | 0.010 | 0.017 | 0.592 |
| Eotaxin levels | 10.516 | 0.724 | 0.005 | 0.012 | 0.661 |
SE, standard error; CTACK, cutaneous T-cell attracting (CCL27); RANTES, regulated on activation, normal T-cell expressed and secreted (CCL5); TRAIL TNF-related apoptosis-inducing ligand.