Table 3.
Primary results for MR analysis of sepsis on circulating cytokines (reverse).
| Method | Beta | SE | OR | 95% CI | P -value | |
|---|---|---|---|---|---|---|
| CTACK levels | Inverse variance weighted | 0.088 | 0.123 | 1.092 | 0.859-1.390 | 0.472 |
| beta-nerve growth factor levels | Inverse variance weighted | -0.193 | 0.124 | 0.825 | 0.647-1.051 | 0.119 |
| Vascular endothelial growth factor levels | Inverse variance weighted | 0.026 | 0.084 | 1.026 | 0.871-1.210 | 0.756 |
| Macrophage Migration Inhibitory Factor levels | Inverse variance weighted | -0.001 | 0.120 | 0.999 | 0.790-1.263 | 0.991 |
| TRAIL levels | Inverse variance weighted | 0.076 | 0.081 | 1.079 | 0.920-1.264 | 0.351 |
| Tumor necrosis factor beta levels | Inverse variance weighted | 0.071 | 0.253 | 1.073 | 0.653-1.762 | 0.780 |
| Tumor necrosis factor alpha levels | Inverse variance weighted | -0.076 | 0.128 | 0.927 | 0.722-1.190 | 0.552 |
| Stromal-cell-derived factor 1 alpha levels | Inverse variance weighted | 0.032 | 0.091 | 1.033 | 0.864-1.235 | 0.723 |
| Stem cell growth factor beta levels | Inverse variance weighted | 0.197 | 0.124 | 1.218 | 0.955-1.552 | 0.112 |
| Stem cell factor levels | Inverse variance weighted | 0.100 | 0.076 | 1.105 | 0.951-1.283 | 0.192 |
| Interleukin-16 levels | Inverse variance weighted | -0.063 | 0.129 | 0.939 | 0.729-1.209 | 0.626 |
| RANTES levels | Inverse variance weighted | -0.031 | 0.122 | 0.970 | 0.763-1.232 | 0.802 |
| Platelet-derived growth factor BB levels | Inverse variance weighted | 0.103 | 0.076 | 1.108 | 0.956-1.285 | 0.174 |
| Macrophage inflammatory protein 1b levels | Inverse variance weighted | 0.049 | 0.117 | 1.050 | 0.835-1.320 | 0.678 |
| Macrophage inflammatory protein 1a levels | Inverse variance weighted | -0.069 | 0.124 | 0.934 | 0.732-1.190 | 0.579 |
| Monokine induced by gamma interferon levels | Inverse variance weighted | -0.050 | 0.176 | 0.951 | 0.674-1.343 | 0.777 |
| Macrophage colony stimulating factor levels | Inverse variance weighted | -0.003 | 0.216 | 0.997 | 0.653-1.522 | 0.989 |
| Monocyte chemoattractant protein-3 levels | Inverse variance weighted | -0.376 | 0.459 | 0.687 | 0.279-1.688 | 0.413 |
| Monocyte chemoattractant protein-1 levels | Inverse variance weighted | 0.029 | 0.085 | 1.029 | 0.871-1.216 | 0.737 |
| Interleukin-12p70 levels | Inverse variance weighted | 0.006 | 0.082 | 1.006 | 0.856-1.182 | 0.943 |
| Interferon gamma-induced protein 10 levels | Inverse variance weighted | -0.049 | 0.126 | 0.952 | 0.743-1.220 | 0.698 |
| Interleukin-18 levels | Inverse variance weighted | 0.074 | 0.113 | 1.077 | 0.863-1.344 | 0.510 |
| Interleukin-17 levels | Inverse variance weighted | 0.090 | 0.085 | 1.094 | 0.927-1.292 | 0.289 |
| Interleukin-13 levels | Inverse variance weighted | -0.239 | 0.126 | 0.787 | 0.615-1.007 | 0.057 |
| Interleukin-10 levels | Inverse variance weighted | -0.021 | 0.093 | 0.979 | 0.816-1.174 | 0.817 |
| Interleukin-8 levels | Inverse variance weighted | -0.069 | 0.114 | 0.934 | 0.746-1.168 | 0.548 |
| Interleukin-6 levels | Inverse variance weighted | -0.045 | 0.083 | 0.956 | 0.813-1.125 | 0.591 |
| Interleukin-1-receptor antagonist levels | Inverse variance weighted | -0.202 | 0.124 | 0.817 | 0.641-1.042 | 0.104 |
| Interleukin-1-beta levels | Inverse variance weighted | -0.146 | 0.094 | 0.864 | 0.719-1.038 | 0.119 |
| Hepatocyte growth factor levels | Inverse variance weighted | -0.072 | 0.079 | 0.931 | 0.798-1.086 | 0.361 |
| Interleukin-9 levels | Inverse variance weighted | -0.158 | 0.124 | 0.854 | 0.669-1.090 | 0.205 |
| Interleukin-7 levels | Inverse variance weighted | -0.096 | 0.154 | 0.909 | 0.673-1.228 | 0.534 |
| Interleukin-5 levels | Inverse variance weighted | -0.164 | 0.150 | 0.848 | 0.632-1.139 | 0.274 |
| Interleukin-4 levels | Inverse variance weighted | 0.059 | 0.083 | 1.061 | 0.902-1.248 | 0.473 |
| Interleukin-2 receptor antagonist levels | Inverse variance weighted | -0.037 | 0.117 | 0.963 | 0.766-1.212 | 0.750 |
| Interleukin-2 levels | Inverse variance weighted | -0.007 | 0.127 | 0.993 | 0.775-1.272 | 0.954 |
| Interferon gamma levels | Inverse variance weighted | 0.062 | 0.088 | 1.064 | 0.896-1.263 | 0.482 |
| Growth-regulated protein alpha levels | Inverse variance weighted | -0.010 | 0.115 | 0.990 | 0.791-1.240 | 0.931 |
| Granulocyte-colony stimulating factor levels | Inverse variance weighted | 0.055 | 0.083 | 1.057 | 0.899-1.243 | 0.502 |
| Fibroblast growth factor basic levels | Inverse variance weighted | 0.046 | 0.085 | 1.047 | 0.886-1.238 | 0.588 |
| Eotaxin levels | Inverse variance weighted | -0.043 | 0.086 | 0.958 | 0.810-1.133 | 0.618 |
MR, mendelian randomization; SE, standard error; OR, odds ratio; CI, confdence interval; CTACK, cutaneous T-cell attracting (CCL27); RANTES, regulated on activation, normal T-cell expressed and secreted (CCL5); TRAIL, TNF-related apoptosis-inducing ligand.