Table 4.
Heterogenity and pleiotropy analyses of sepsis on circulating cytokines (reverse).
| Heterogenity | MR-Egger intercept | ||||
|---|---|---|---|---|---|
| Q | Q_pvalue | Egger_intercept | SE | P -value | |
| CTACK levels | 8.626 | 0.375 | 0.027 | 0.025 | 0.311 |
| beta-nerve growth factor levels | 10.155 | 0.338 | -0.021 | 0.026 | 0.451 |
| Vascular endothelial growth factor levels | 7.820 | 0.552 | 0.017 | 0.017 | 0.350 |
| Macrophage Migration Inhibitory Factor levels | 3.086 | 0.929 | -0.003 | 0.025 | 0.922 |
| TRAIL levels | 5.240 | 0.813 | -0.011 | 0.017 | 0.538 |
| Tumor necrosis factor beta levels | 2.919 | 0.571 | -0.175 | 0.143 | 0.309 |
| Tumor necrosis factor alpha levels | 6.101 | 0.636 | 0.013 | 0.027 | 0.641 |
| Stromal-cell-derived factor 1 alpha levels | 11.099 | 0.269 | -0.010 | 0.020 | 0.620 |
| Stem cell growth factor beta levels | 7.917 | 0.442 | 0.035 | 0.026 | 0.213 |
| Stem cell factor levels | 4.236 | 0.895 | -0.012 | 0.016 | 0.470 |
| Interleukin-16 levels | 5.774 | 0.673 | 0.025 | 0.028 | 0.395 |
| RANTES levels | 9.402 | 0.401 | 0.027 | 0.025 | 0.312 |
| Platelet-derived growth factor BB levels | 9.541 | 0.482 | 0.008 | 0.016 | 0.639 |
| Macrophage inflammatory protein 1b levels | 23.445 | 0.009 | 0.010 | 0.025 | 0.701 |
| Macrophage inflammatory protein 1a levels | 3.523 | 0.940 | 0.025 | 0.026 | 0.362 |
| Monokine induced by gamma interferon levels | 16.230 | 0.059 | 0.027 | 0.038 | 0.499 |
| Macrophage colony stimulating factor levels | 13.500 | 0.061 | 0.032 | 0.048 | 0.523 |
| Monocyte chemoattractant protein-3 levels | 9.322 | 0.054 | -0.095 | 0.295 | 0.769 |
| Monocyte chemoattractant protein-1 levels | 3.110 | 0.875 | 0.015 | 0.018 | 0.439 |
| Interleukin-12p70 levels | 2.570 | 0.958 | 0.007 | 0.017 | 0.678 |
| Interferon gamma-induced protein 10 levels | 10.775 | 0.291 | -0.008 | 0.028 | 0.767 |
| Interleukin-18 levels | 5.590 | 0.848 | 0.021 | 0.023 | 0.392 |
| Interleukin-17 levels | 9.080 | 0.430 | 0.007 | 0.019 | 0.726 |
| Interleukin-13 levels | 4.788 | 0.780 | 0.037 | 0.026 | 0.198 |
| Interleukin-10 levels | 9.412 | 0.309 | -0.001 | 0.021 | 0.957 |
| Interleukin-8 levels | 8.135 | 0.616 | 0.030 | 0.024 | 0.234 |
| Interleukin-6 levels | 7.137 | 0.522 | 0.006 | 0.017 | 0.745 |
| Interleukin-1-receptor antagonist levels | 3.290 | 0.915 | 0.000 | 0.026 | 0.993 |
| Interleukin-1-beta levels | 9.218 | 0.417 | 0.041 | 0.019 | 0.062 |
| Hepatocyte growth factor levels | 4.966 | 0.761 | -0.022 | 0.016 | 0.226 |
| Interleukin-9 levels | 4.223 | 0.836 | 0.027 | 0.026 | 0.326 |
| Interleukin-7 levels | 9.510 | 0.218 | 0.038 | 0.032 | 0.275 |
| Interleukin-5 levels | 12.607 | 0.181 | 0.076 | 0.027 | 0.021 |
| Interleukin-4 levels | 9.211 | 0.418 | 0.008 | 0.018 | 0.668 |
| Interleukin-2 receptor antagonist levels | 3.139 | 0.925 | 0.005 | 0.024 | 0.840 |
| Interleukin-2 levels | 1.905 | 0.984 | 0.000 | 0.026 | 0.989 |
| Interferon gamma levels | 11.091 | 0.270 | -0.007 | 0.019 | 0.737 |
| Growth-regulated protein alpha levels | 7.117 | 0.714 | 0.038 | 0.024 | 0.146 |
| Granulocyte-colony stimulating factor levels | 3.133 | 0.959 | -0.006 | 0.017 | 0.720 |
| Fibroblast growth factor basic levels | 4.690 | 0.860 | 0.004 | 0.018 | 0.835 |
| Eotaxin levels | 2.731 | 0.909 | 0.000 | 0.018 | 0.996 |
SE, standard error; CTACK, cutaneous T-cell attracting (CCL27); RANTES, regulated on activation, normal T-cell expressed and secreted (CCL5); TRAIL TNF-related apoptosis-inducing ligand.