Skip to main content
. 2023 Oct 30;7(1):e202302222. doi: 10.26508/lsa.202302222

Figure 2. Phenotype of myeloid-specific (M-triple) KO mice.

Figure 2.

(A, B) Growth curves of (A) male control (N = 19) and M-triple KO (N = 14) mice and (B) female control (N = 18) and M-triple KO (N = 20) mice. Mice were weighed weekly, and weights are shown as means ± SD over time (weeks). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, determined by two-way ANOVA with Šídák’s multiple comparison test. (C) Mice were monitored weekly for swollen or red paws, and the arthritis prevalence is shown as a percentage of M-triple KO male (N = 15) and M-triple KO female (N = 8) mice with swollen paws at a given age (in weeks). (D) Percent survival of control male (N = 55), M-triple KO male (N = 26), control female (N = 74), and M-triple KO female (N = 28) mice at a given age (weeks). (E) Photographs of front and hind paws of live male and female control and M-triple KO mice at 10 wk of age. (F) Spleen weights shown in mg as mean ± SD, and example photographs of markedly enlarged spleens from M-triple KO mice (bottom) compared to control spleen (top), both from 9-wk-old mice. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, determined by unpaired, two-tailed t tests with Welch’s correction.