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. 2023 Oct 30;7(1):e202302222. doi: 10.26508/lsa.202302222

Figure S1. Phenotype of myeloid-specific double KO mice.

Figure S1.

(A) Percent survival of control male (N = 60), M-triple KO male (N = 26), (Zfp36flox/wt; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre+/−) male (N = 4), (Zfp36flox/flox; Zfp36l1flox/wt; Zfp36l2flox/flox; LysM-Cre+/−) male (N = 7), (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/wt; LysM-Cre+/−) (N = 4), control female (N = 79), M-triple KO female (N = 28), (Zfp36flox/wt; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre+/−) female (N = 9), (Zfp36flox/flox; Zfp36l1flox/wt; Zfp36l2flox/flox; LysM-Cre+/−) female (N = 9), and (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/wt; LysM-Cre+/−) female (N = 9) mice at a given age (weeks). Abbreviations for genotypes used in this figure are as follows: control (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre−/−), M-triple KO (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre+/−), TTP Het/L1 KO/L2 KO (Zfp36flox/wt; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre+/−), TTP KO/L1 Het/L2 KO (Zfp36flox/flox; Zfp36l1flox/wt; Zfp36l2flox/flox; LysM-Cre+/−), and TTP KO/L1 KO/L2 Het (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/wt; LysM-Cre+/−). (B) Photographs of front and hind paws of live male and female controls (24 wk of age), (Zfp36flox/flox; Zfp36l1flox/wt; Zfp36l2flox/flox; LysM-Cre+/−) (24 wk of age), and M-triple KO (9 wk of age) mice. The abbreviations above refer to the following genotypes: control (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre−/−), TTP/L2 KO (Zfp36flox/flox; Zfp36l1flox/WT; Zfp36l2flox/flox; LysM-Cre+/−), and M-triple KO (Zfp36flox/flox; Zfp36l1flox/flox; Zfp36l2flox/flox; LysM-Cre+/−).