Average CEST Z-spectra (or Slab) and the corresponding Sref for the multiple-pool Lorentzian fitting of APT (a) and NOE(−3.5) (b) from tumors and contralateral normal tissues of the eight rats with a value of , as well as the fitting residuals. The CESTRI, CESTRΠ, and AREX spectra obtained from these Z-spectra for APT (c, e, g) and NOE(−3.5) (b, f, h), respectively.