Table 3.
Factor | Overall survival | Progression-free survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR(95%CI) | P value | HR(95%CI) | P value | HR(95%CI) | P value | HR(95%CI) | P value | |
Treatment option | ||||||||
T+L+C/T+C/TACE | 0.47(0.38-0.60) | <0.001 | 0.49(0.39-0.62) | <0.001 | 0.57(0.46-0.71) | <0.001 | 0.59(0.48-0.73) | <0.001 |
Age | 0.99(0.97-1.01) | 0.297 | 1.00(0.98-1.02) | 0.751 | ||||
Sex | ||||||||
Female/Male | 0.79(0.48-1.29) | 0.346 | 0.66(0.42-1.03) | 0.069 | 0.80(0.50-1.27) | 0.342 | ||
Etiology | ||||||||
Hepatitis B/Others | 1.31(0.81-2.12) | 0.273 | 1.21(0.78-1.87) | 0.392 | ||||
Cirrhosis | ||||||||
Yes/No | 1.10(0.70-1.73) | 0.687 | 1.22(0.80-1.86) | 0.362 | ||||
ECOG PS score | ||||||||
2/1 | 0.98(0.65-1.49) | 0.929 | 1.08(0.73-1.58) | 0.711 | ||||
Child-Pugh class | ||||||||
B/A | 1.26(0.65-2.44) | 0.493 | 1.05(0.56-1.95) | 0.889 | ||||
ALBI grade | ||||||||
3/2/1 | 1.00(0.69-1.45) | 0.983 | 0.97(0.69-1.37) | 0.851 | ||||
portal vein invasion | ||||||||
Yes/No | 2.62(1.69-4.05) | <0.001 | 2.54(1.63-3.94) | <0.001 | 2.46(1.67-3.62) | <0.001 | 2.46(1.67-3.62) | <0.001 |
Extrahepatic metastasis | ||||||||
Yes/No | 1.07(0.71-1.62) | 0.754 | 1.10(0.76-1.62) | 0.610 | ||||
Number of tumors | ||||||||
3/2/1 | 1.04(0.84-1.27) | 0.749 | 0.98(0.81-1.18) | 0.803 | ||||
Largest tumor size (cm) | ||||||||
≥10/<10 | 1.00(1.00-1.01) | 0.425 | 1.00(1.00-1.01) | 0.499 | ||||
AFP level (μg/L) | ||||||||
≥400/<400 | 1.25(0.84-1.85) | 0.278 | 1.11(0.78-1.60) | 0.563 |
Analyses were performed using Cox proportional hazard regression model. HR, hazard ratio; CI, confidence interval; T+L+C, transarterial chemoembolization combined with lenvatinib plus camrelizumab; T+C, transarterial chemoembolization combined with camrelizumab; TACE, transarterial chemoembolization; ECOG-PS, Eastern Cooperative Oncology Group performance status; AFP, alpha-fetoprotein. HR and P values that are meaningful for multivariate analyses are in bold; bold is for eye-catching.