Table 2.

Patients with Alzheimer’s disease (AD) reporting mania or hypomania after acetylcholinesterase inhibitor treatment.

References	Age	Sex	Diagnosis	MD (Onset)	AChEI	DD	Concomitant Drugs (Duration)	Time to Mania	PS	Time to Resolution	Treatment
Ehrt et al. (2011) [27]	81	F	AD	BD 1 (40 y)	Rivastigmine	4.6 mg	Venlafaxine, lithium (2 y)	1 week	No	1 week	None
Ehrt et al. (2011) [27]	76	M	AD	BD 1 (adolescence)	Galantamine	16 mg	Escitalopram, lithium (1 y)	9 days after increase	No	2 weeks	None
Tseng and Tzeng (2012) [28]	79	M	AD	None	Rivastigmine	3 mg	None	3 days	No	2 days	None
Hategan and Bourgeois (2016) [30]	72	F	Mixed dementia	MDE (64 y)	Donepezil	10 mg	Duloxetine (8 y)	1 week after increase	Yes	17 days	Risperidone
Jalal et al. (2017) [29]	79	F	Mixed dementia	BD 1 (74 y)	Galantamine	8 mg	Divalproex	2 weeks	No	4 weeks	Divalproex increase and risperidone
Faisal et al. (2017) [31]	92	F	AD	Depressive symptoms	Donepezil	10 mg	Memantine	Many months	Yes	Rapid	Quetiapine (failed trial)

Abbreviations: AChEI = Acetylcholinesterase inhibitor, AD = Alzheimer’s disease, BD 1 = Bipolar disorder type 1, DD = Daily dose, F = Female; M = male, MDE: Major depressive episode, MD = Mood disorder, PS = Psychotic symptoms, y = years.