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. 2023 Oct 17;10:1195026. doi: 10.3389/fmed.2023.1195026

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Copyright © 2023 Zandi, Shojaeian, Abbasvandi, Faranoush, Anbiaee, Hoseinpour, Gilani, Saghafi, Zandi, Hoseinyazdi, Davari, Miraghaie, Tayebi, Taheri, Ardestani, Sheikhi Mobarakeh, Nikshoar, Enjavi, Kordehlachin, Mousavi-kiasary, Mamdouh, Akbari, Yunesian and Abdolahad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) TREND flow diagram of the positive electrostatic charge complementary therapy, human study. (B) Schematic representation of the PECT setup. A hospitalized patient is depicted alongside the PEC generator unit. A patch is applied to the patient’s skin over the tumor site and is connected to the generator unit via a connection cable. The detailed diagram zooms in on the patch, revealing its multiple layers. These layers consist of anti-allergic surgical tape and PDMS both serve to protect and insulate a flexible metallic sheet contained within the patch. This metallic sheet plays a crucial role in accumulating PEC directly over the tumor site as part of the therapeutic process.