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. 2023 Oct 31;21:398. doi: 10.1186/s12951-023-02177-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Biodistribution of PLGA-Exos in mice with PE particles-induced mouse calvarial osteolysis. (A, B) Representative fluorescence images after local injections of DiR-labeled Exos (200 µg) and PLGA-Exos (200 µg), and quantification of the fluorescent intensity. (C, D) Representative IVIS images showed the distribution of the calvarial region of the mouse and the quantification of the fluorescent intensity. (n = 3 samples per group, t-test, *P < 0.05, ** P < 0.01, *** P < 0.001) (E, F) Representative IVIS images showed the distribution of Exos and PLGA-Exos in the main organs after PE particle-induced calvarial osteolysis. (n = 3 samples per group, *P < 0.05, ** P < 0.01, *** P < 0.001)