Table 1.
Baseline characteristics of the patients
| Characteristic | Haloperidol (n = 65) | Placebo (n = 67) |
|---|---|---|
| Age, median (IQR), year | 66 (57–75.5) | 68 (60–74) |
| Male, n (%) | 48 (74) | 42 (63) |
| Location before ICU admission | ||
| Hospital ward, n (%) | 29 (45) | 31 (46) |
| Operation room/recovery, n (%) | 17 (26) | 18 (27) |
| ED, n (%) | 12 (19) | 11 (16) |
| Other, n (%) | 7 (11) | 7 (10) |
| Type of ICU admission | ||
| Medical, n (%) | 36 (55) | 39 (58) |
| Emergency surgery, n (%) | 17 (26) | 17 (25) |
| Elective surgery, n (%) | 12 (19) | 11 (16) |
| ICU admission diagnosis | ||
| Respiratory, n (%) | 24 (37) | 28 (42) |
| Gastrointestinal, n (%) | 14 (22) | 10 (15) |
| Cardiovascular, n (%) | 9 (14) | 16 (24) |
| Transplant, n (%) | 7 (11) | 5 (8) |
| Trauma, n (%) | 5 (8) | 1 (2) |
| Other, n (%) | 6 (9) | 7 (10) |
| APACHE IV score, median (IQR) | 70 (57–90.5) | 77 (55–99) |
| mSOFA score at randomization, median (IQR) | 5 (3–7)* | 6 (4–9) |
| Baseline QTc at randomization, mean (SD) | 428.9 (29.9) | 421.3 (32.1) |
| No. of days from ICU admission to randomization, median (IQR) | 4 (2–10.5) | 6 (3–9) |
APACHE acute physiology and chronic health evaluation, ED emergency department, ICU intensive care unit, mSOFA modified sequential organ failure assessment (without the central nervous system component), SOFA sequential organ failure assessment, Yr year
*Significantly differed from the placebo group (p < 0.05)