Supplementary Table 1.

Baseline characteristics of the study participants according to incident kidney function decline.

	Incident eGFR decline		P value
	No (n=128 233)	Yes (n=3890)
Age, years	56.48±8.94	62.11±9.53	<0.001
Female (%)	83860 (65.40)	2461 (63.26)	0.006
Current smoking (%)	19434 (15.16)	506 (13.01)	<0.001
Current drinking (%)	13685 (10.67)	303 (7.79)	<0.001
MVPA (hour/week)	1.40±4.99	1.41±4.56	0.912
Sitting time (h/week)	28.97±16.37	29.63±16.28	0.014
BMI (kg/m2)	24.63±3.62	25.08±3.56	<0.001
WC (cm)	83.97±9.83	85.41±9.79	<0.001
SBP (mmHg)	132.9±20.65	141.1±22.72	<0.001
DBP (mmHg)	78.45±11.12	80.47±11.69	<0.001
FPG (mmol/L)	5.94±1.59	6.33±2.12	<0.001
2hPG (mmol/L)	8.20±3.78	9.40±4.76	<0.001
HbA1c (%)	6.00±1.00	6.31±1.31	<0.001
TC (mmol/L)	4.96±1.13	4.84±1.43	<0.001
TG (mmol/L)	1.31 (0.93–1.91)	1.40 (0.96–2.01)	<0.001
HDL-C (mmol/L)	1.34±0.36	1.21±0.39	<0.001
LDL-C (mmol/L)	2.88±0.87	2.82±1.03	<0.001
Cr (μmol/L)	65.57±11.91	70.89±17.57	<0.001
eGFR (mL/min/1.73 m2)	95.50±11.60	86.62±17.26	<0.001
Prevalence of hypertension (%)	56731 (44.24)	2443 (62.80)	<0.001
Prevalence of diabetes (%)	29319 (22.86)	1370 (35.22)	<0.001
Prevalence of dyslipidemia (%)	54163 (42.24)	2183 (56.12)	<0.001

Continuous variables are expressed as the mean (standard deviation) or median (IQR), and categorical variables are expressed as the number (percentage). eGFR – estimated glomerular filtration rate; MVPA – moderate or vigorous intensity physical activity; BMI – body mass index; WC – waist circumference; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting blood glucose; 2hPG – 2 hours postprandial blood glucose; TG – triglycerides; TC – total cholesterol; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; Cr – creatinine.