Supplementary Table 2.
Sensitivity analysis of associations between sitting time and kidney function decline-1 (n=110 721).
| Quartile 1 (n=27 531) | Quartile 2 (n=22 705) | Quartile 3 (n=31 704) | Quartile 4 (n=28 781) | P for trend | |
|---|---|---|---|---|---|
| Cases | 598 (2.2%) | 520 (2.3%) | 765 (2.4%) | 744 (2.6%) | 0.010 |
| Model 1 | 1 | 1.028 (0.914–1.156) | 1.059 (0.952–1.179) | 1.070 (0.961–1.192) | 0.183 |
| Model 2 | 1 | 1.039 (0.921–1.172) | 1.089 (0.976–1.215) | 1.198 (1.074–1.338) | <0.001 |
| Model 3 | 1 | 1.025 (0.906–1.161) | 1.070 (0.955–1.198) | 1.173 (1.048–1.314) | 0.004 |
The outcome was defined as an eGFR <60 mL/min/1.73 m2 at follow-up or more than a 30% decrease in eGFR from baseline, CKD-related hospitalization or death, or the presence of end-stage renal disease. In this analysis, participants with cancer, cardiovascular diseases, stroke, chronic respiratory diseases, and liver cirrhosis at baseline were excluded. Quartiles of sitting time: 1st quartile ≤17.4 h/week, 2nd quartile=17.5–27.9 h/week, 3rd quartile=28.0–36.9 h/week, 4th quartile ≥37 h/week. Model 1: Crude HR. Model 2: Adjusted for age, sex, current smoking, and current drinking. Model 3: Adjusted for covariates in model 2 plus BMI, hypertension, diabetes, dyslipidemia and MVPA. HR – hazard ratio; CI – confidence interval.