Supplementary Table 3.
Sensitivity analysis of associations between sitting time and kidney function decline-2 (n=132 123).
| Quartile 1 (n=32 947) | Quartile 2 (n=27 162) | Quartile 3 (n=37 810) | Quartile 4 (n=34 204) | P for trend | |
|---|---|---|---|---|---|
| Cases | 894 (2.7%) | 767 (2.8%) | 1153 (3.1%) | 1076 (3.2%) | 0.003 |
| Model 1 | 1 | 1.013 (0.920–1.116) | 1.079 (0.989–1.177) | 1.052 (0.963–1.150) | 0.137 |
| Model 2 | 1 | 1.018 (0.924–1.121) | 1.097 (1.005–1.197) | 1.154 (1.056–1.261) | <0.001 |
| Model 3 | 1 | 1.004 (0.911–1.106) | 1.077 (0.987–1.175) | 1.135 (1.038–1.240) | 0.002 |
The outcome was defined as an eGFR <60 mL/min/1.73 m2 and a rate of decline more than 1 mL/min/1.73 m2 per year, CKD-related hospitalization or death, or the presence of end-stage renal disease. Analysis was done after imputing for missing information. Quartiles of sitting time: 1st quartile ≤17.4 h/week, 2nd quartile=17.5–27.9 h/week, 3rd quartile=28.0–36.9 h/week, 4th quartile ≥37 h/week. Model 1: Crude HR. Model 2: Adjusted for age, sex, current smoking, and current drinking. Model 3: Adjusted for covariates in Model 2 plus BMI, hypertension, diabetes, dyslipidemia and MVPA. HR – hazard ratio; CI – confidence interval.