Table 4.
Causal mediation analysis for the effect of 24-week changes in fatigue on 24-week changes in functional outcomes.
| Total effect | Direct effect | Indirect effect | Percentage mediated | ||||
|---|---|---|---|---|---|---|---|
| Effect size (95% CI) | p-value | Effect size (95% CI) | p-value | Effect size (95% CI) | p-value | ||
| MSFC | 0.22 (−0.03, 0.46) | 0.09 | 0.05 (−0.22, 0.32) | 0.98 | 0.16 (0.02, 0.31) | 0.02 | 76.2% |
| NHPT | −0.82 (−3.31, 1.68) | 0.52 | 1.21 (−1.51, 3.93) | 0.38 | −2.03 (−3.55, −0.50) | 0.009 | 249% |
| SDMT-O | 2.44 (−0.72, 5.61) | 0.13 | 0.60 (−2.95, 4.16) | 0.74 | 1.84 (−0.03, 3.71) | 0.06 | 75.3% |
| T25FW | −0.62 (−1.86, 0.62) | 0.33 | −0.33 (−1.72, 1.06) | 0.64 | −0.29 (−0.96, 0.38) | 0.40 | 46.8% |
| 6MWT | 22.7 (−13.2, 58.4) | 0.22 | −12.2 (−50.1, 25.6) | 0.35 | 34.9 (12.3, 57.5) | 0.003 | 154% |
Abbreviations: MSFC = multiple sclerosis functional composite; NHPT = nine-hole peg-test; SDMT-O = oral symbol digit modalities test; T25FW = timed 25-foot walk; 6MWT = 6-min walk test.