Fig 2.

RRV is selectively resistant to homologous enteric α-defensins. RRV was incubated with the indicated concentrations of (A) RED1, (B) RED3, (C) RMAD1, (D) RMAD4, (E) HD5, (F) HNP1, or (G) Crp2 before infecting MA104 cells (protocol 1; solid, colored lines). For protocol 2 (dotted, black lines with filled circles), RRV was bound to cells in the cold prior to defensins being added (A and D–G). (H) HPV16 pseudovirus infection was measured in the presence of RED1 and RED3 following protocol 1. Data are normalized to infection in the absence of defensin (control infection) and are the mean ± SD of at least three individual experiments.