TABLE 1.

The designed grafting schemes to construct the GII.4-GI.1 chimeric VLPs

Scheme no.	Loops	Grafting residues of GII.4	The residues to be substituted in GI.1
N1	loop1	336QTTRTDGSTRG346	333TQFGHSSQ340
N2	loop1	338TRTDGST344	334QFGHSS339
N3	loop1	337TTRTDGST344	334QFGHSS339
N4	loop1	338TRTDGS343	335FGH337
N5	loop2	367FETDTDRDFEA377	361ANGIGS366
N6	loop2	366QFETDTDRDF375	361ANGIG365
N7	loop3	290VTHITGSRNYTM301	295NGTV298
N8	loop3	291THITGSRNYT300	296GT297
N9	loop4	390QDGSTTHRNEP400	378PPSHPSGSQV387
N10	loop4	390QDGSTTHRNE399	378PPSHPSGSQ386
N11	loop5	440GCSGYPNM447	427GPGAY431
N12	loop5	440GCSGYPNMDL449	427GPGAYN432
N13	loop6	409SGRNTPNV416	396GSSITEAT403
N14	loop7	247EKLFTGPSSAFVVQ260	252SMGISPDNVQSV263
N15	loop8	352YTGSADFA359	346DTTPDTFV353