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A model for SPOP-mediated inhibition of EV71 infection. EV71 viruses encode 2Apro to aid packaging to produce viral particles. Host ubiquitin E3 ligase SPOP interacts with EV71-2Apro and induces K48-linked polyubiquitination of EV71-2Apro, which results in the degradation of EV71-2Apro via the lysosomal pathway. SPOP-mediated degradation of EV71-2Apro ultimately inhibits EV71 infection. Created with BioRender.com.
