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. 2023 Oct 27;16:867–883. doi: 10.2147/OTT.S429128

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© 2023 Zhang et al.

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B7 inhibits autophagy of CRC cells by inhibiting Beclin-1. (A) The morphology of mitochondria was observed by transmission electron microscope. The red arrow indicated that mitochondria in group B7 showed pyknosis, vacuolation, and membrane rupture. (B) The expression of the autophagy-related gene Beclin-1 was detected by qPCR. (C) The expression of the ferroptosis-related gene XCT was detected by qPCR. (D) Expression levels of XCT, Beclin-1, and GAPDH proteins were assessed via Western blotting. The data are represented as the mean ± SD (n = 3). Statistical differences were considered significant at ***p < 0.001.