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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Mol Genet Metab. 2023 Jan 13;138(2):107508. doi: 10.1016/j.ymgme.2023.107508

Figure 3. Neurodegeneration in Glb1−/−.

Figure 3.

a. Representative sagittal T1 MRI images of GM1 patient at one year and eleven months old and four years and three months old. b. Representative sagittal T1 MRI images of Glb1+/+ and Glb1−/− mice. c. Estimated white matter volume of the corpus callosum region from T1 MRI images of late infantile and juvenile GM1 patients (mm3). d and e. ITK-Snap quantification of mouse T2 MRI images: d. estimated white matter in corpus callosum region and e. cerebellum volumes (mm3) for of 8-, 20- and 32-week-old mice (± SEM, two-tailed unpaired t-test with Welch’s correction).