Figure 4. Increased pentasaccharide levels.
a. Structure of H3N2a and H3N2b pentasaccharides. Pentasaccharide levels in b. and c. urine, d. and e. plasma and f. and g. CSF samples from control and GM1 juvenile and late infantile patients; Data are presented as mean ± SD for n = 4–20 (CSF), n = 4–10 (plasma) and n = 4–10 (urine) of GM1 juvenile, late infantile and control samples (two-tailed unpaired Mann-Whitney t-test). Pentasaccharide levels in h. and i. urine and j. and k. plasma from Glb1+/+ and Glb1−/− mice. Data are presented as mean ± SD for n = 7–9 (urine) and n = 9–20 (plasma) of 8-, 20- and 32-week-old mice (two-tailed unpaired t-test with Welch’s correction).
