. Author manuscript; available in PMC: 2024 Feb 1.

Published in final edited form as: Mol Genet Metab. 2023 Jan 13;138(2):107508. doi: 10.1016/j.ymgme.2023.107508

Table 1.

Similarities between Glb1 knockout and GM1 gangliosidosis Type II patients

Glb1 knockout mouse	GM1 gangliosidosis Type II patients
Premature death (adults)	Premature death (teen and adults)
Progressive gait disturbance	Progressive gait disturbance
Loss of strength and coordination	Loss of strength and coordination
Cerebellar and corpus callosum atrophy	Global brain atrophy
H3N2a and H3N2b biomarker elevation (serum and urine)	H3N2a and H3N2b biomarker elevation (serum, urine and CSF)
Progressive elevation of GM1 gangliosides and its related charged glycosphingolipids	GM1 and GA1 elevation in postmortem nervous tissue [40–42]