Figure S1.
Analysis of subgenome-resolved SARS-CoV-2 RNA-protein interactions, related to Figure 1
(A) Enrichment of reads mapping to SARS-CoV-2 positive-sense or negative-sense RNA in gRNA purifications relative to sgmRNA purifications ± SE. p values determined by Wald test.
(B) Venn diagram comparing two UV-based SARS-CoV-2 RNA interactomes7,9 to the subgenome-resolved RNA interactome presented in this study (Huh-7 cells, FDR < 5%, Table S2). Only human proteins are shown.
(C) Total number of connections observed in protein-protein association network constructed based on consensus SARS-CoV-2 RNA interactome (red line, 1,280 connections), compared to number of connections observed in random networks of equal size (gray bars, mean 259.9 connections) using random sampling of proteins detected in proteome measurements (1,000 permutations).