Fig. 3.

CpG island methylator phenotype (CIMP) clustering of 294 tumor samples. (A) Heatmap of 294 CRC samples based on the methylation level of CIMP marker probes. Samples were clustered in each CIMP-based group and sorted according to MLH1 methylation level. (B) Boxplot of the mean methylation levels of CIMP marker genes, according to the CIMP and MSI statuses. (C) Proportions of samples with the MSI and MSS statuses according to the CIMP status. (D) Boxplot of the distribution of MLH1 methylation according to the CIMP and MSI statuses. (E) Distribution of tissue location among the CIMP groups. Tumors at descending, rectosigmoid, and sigmoid colon are considered left-sided, and those at cecum, ascending colon, and transverse colon are considered right-sided. Synchronous tumors occurred as multiple tumors on both left and right sides simultaneously.