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. 2023 Oct 31;14:6934. doi: 10.1038/s41467-023-42532-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The loci are colored by the lipid class from the univariate analysis and labeled by the cluster number from the multivariate analysis. The x-axis shows the P-values of the top associated univariate lead variant of the loci. The y-axis shows the P-values of the top associated multivariate lead variant of the loci. Two-sided P-values were calculated using a linear-mixed-model (uv) and canonical correlation analysis (mv). If no variant reached P < 5e-8 for the locus in univariate analysis, the minimum univariate P-value of the lead variant of the multivariate analysis is shown. Known loci and novel loci are annotated by the locus name in black and red, respectively. Dark blue dashed lines represent the genome-wide significance level (P < 5e-8) and dark blue dot-dashed lines represent the multiple testing-corrected significance level (uv: 7.352941e-10, mv: 4.545455e-9). Black line shows the diagonal. The lipid class names are listed in Fig. 1. The axes are capped at 300.