Table 1.
Loci reaching the Bonferroni-corrected significance level
| Locus | Chr | Mv trait | Mv lead variant | Mv minP | Uv trait | Uv lead variant | Uv minP | HDL | LDL | TC | TG | LS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RF00019 | 1 | 4 | rs7529794 | 1e-12 | LPE 18:0;0 | rs7529794 | 4e-13 | X | X | |||
| PCSK9 | 1 | 7 | rs11591147 | 3e-23 | SM 34:1;2 | rs11591147 | 2e-19 | X | X | X | ||
| DOCK7 | 1 | 2 | rs3913007 | 4e-28 | PI 18:0;0_20:4;0 | rs1168104 | 6e-25 | X | X | X | X | X |
| AC105942.1 | 1 | 5 | rs1265169 | 1e-25 | PC 18:0;0_18:2;0 | rs34396223 | 7e-13 | X | ||||
| DTL | 1 | 5 | rs116329252 | 4e-11 | PC 18:0;0_18:2;0 | rs116329252 | 3e-5 | |||||
| MARC1 | 1 | 1 | rs2642442 | 4e-8 | TAG 54:4;0 | rs2642442 | 5e-11 | X | X | X | X | |
| GALNT2 | 1 | 10 | rs6672758 | 2e-9 | PC O-16:1;0/18:1;0 | rs6672758 | 4e-10 | X | X | X | ||
| APOB | 2 | 7 | rs1367117 | 4e-11 | CE 16:0;0 | rs1367117 | 3e-9 | X | X | X | X | X |
| GCKR | 2 | 3 | rs1260326 | 1e-17 | TAG 50:4;0 | rs1260326 | 4e-22 | X | X | X | X | X |
| ABCG8 | 2 | 9 | rs4245791 | 3e-32 | CE 20:2;0 | rs4245791 | 9e-32 | X | X | X | X | |
| STK39 | 2 | 8 | rs143928330 | 3e-10 | SM 34:2;2 | rs143928330 | 1e-5 | |||||
| AC021074.3 | 3 | 2 | rs12638256 | 1e-39 | PI 18:0;0_18:1;0 | rs12638256 | 5e-20 | X | X | X | X | |
| ANKRD17 | 4 | 8 | rs187918276 | 4e-15 | SM 40:1;2 | rs187918276 | 3e-17 | X | X | X | X | |
| CDS1 | 4 | 2 | rs191460656 | 2e-9 | PI 16:0;0_18:2;0 | rs191460656 | 3e-5 | |||||
| ELOVL6 | 4 | 3 | rs5022521 | 5e-33 | CE 16:1;0 | rs5022521 | 3e-7 | X | X | |||
| SMIM13 | 6 | 6 | rs9468401 | 6e-20 | CE 22:6;0 | rs9468401 | 2e-5 | X | ||||
| AGPAT1 | 6 | 3 | rs1061808 | 4e-31 | TAG 50:1;0 | rs1061808 | 4e-9 | X | X | X | X | X |
| PEX6 | 6 | 6 | rs9462860 | 5e-13 | PC 18:0;0_22:6;0 | rs4987173 | 3e-9 | X | X | X | X | |
| NPC1L1 | 7 | 8 | rs41279633 | 9e-11 | CE 18:0;0 | rs17725246 | 4e-8 | X | X | |||
| MLXIPL | 7 | 8 | rs3812316 | 9e-12 | DAG 18:1;0_18:2;0 | rs13235543 | 9e-11 | X | X | X | X | |
| AC022784.1 | 8 | 3 | rs4841133 | 4e-13 | PC 18:0;0_18:2;0 | rs4841133 | 9e-8 | X | X | X | X | X |
| LPL | 8 | 1 | rs3916027 | 2e-10 | TAG 56:6;0 | rs10105606 | 2e-12 | X | X | X | X | X |
| ERMP1 | 9 | 8 | rs142911112 | 1e-20 | SM 32:1;2 | rs140094646 | 1e-8 | X | X | |||
| ABO | 9 | 8 | rs977371848 | 2e-10 | CE 18:0;0 | rs992108547 | 7e-14 | X | X | X | X | |
| AGPAT2 | 9 | 3 | rs2236514 | 2e-12 | PC 16:0;0_22:5;0 | rs2236514 | 4e-12 | |||||
| JMJD1C | 10 | 8 | rs10822163 | 4e-9 | Cer 42:2;2 | rs10822163 | 4e-6 | X | X | X | X | |
| SGPL1 | 10 | 8 | rs12763964 | 6e-17 | Cer 42:2;2 | rs12763964 | 2e-10 | |||||
| PKD2L1 | 10 | 3 | rs603424 | 4e-26 | PC 16:1;0_18:1;0 | rs603424 | 1e-11 | X | X | |||
| GPAM | 10 | 2 | rs7096937 | 1e-13 | PI 18:0;0_20:4;0 | rs7096937 | 1e-5 | X | X | X | X | |
| PNLIPRP2 | 10 | 3 | rs4751995 | 9e-12 | PC 16:0;0_18:2;0 | rs4751995 | 1e-6 | X | X | X | X | |
| FADS2 | 11 | 7 | rs174562 | 1e-783 | PC 18:0;0_20:4;0 | rs174537 | 1e-438 | X | X | X | X | X |
| CPT1A | 11 | 3 | rs2229738 | 9e-18 | CE 20:4;0 | rs2229738 | 7e-11 | X | X | X | ||
| RN7SL786P | 11 | 3 | rs10160784 | 2e-14 | PC 18:1;0_20:2;0 | rs656095 | 4e-9 | X | X | X | ||
| ZPR1 | 11 | 3 | rs964184 | 3e-42 | TAG 54:4;0 | rs964184 | 9e-39 | X | X | X | X | X |
| SOAT2 | 12 | 8 | rs11170421 | 7e-35 | CE 18:0;0 | rs2280696 | 4e-24 | X | ||||
| HNF1A | 12 | 8 | rs1169306 | 6e-22 | SM 38:2;2 | rs1169306 | 4e-12 | X | X | X | X | |
| AL161670.1 | 14 | 8 | rs7157785 | 2e-197 | SM 32:1;2 | rs7157785 | 3e-95 | X | X | X | X | |
| LIPC | 15 | 2 | rs10468017 | 2e-126 | PE 16:0;0_20:4;0 | rs2043085 | 4e-104 | X | X | X | X | X |
| NTAN1 | 16 | 3 | rs1136001 | 1e-52 | CE 20:3;0 | rs1135999 | 2e-36 | X | X | X | ||
| CETP | 16 | 3 | rs17231506 | 1e-33 | PC 16:0;0_18:2;0 | rs17231506 | 8e-15 | X | X | X | X | X |
| LCAT | 16 | 7 | rs4986970 | 1e-16 | CE 20:4;0 | rs4986970 | 2e-4 | X | X | |||
| GLTPD2 | 17 | 8 | rs79202680 | 1e-79 | SM 40:1;2 | rs79202680 | 4e-60 | X | X | X | X | |
| KCNJ12 | 17 | 7 | rs6587148 | 2e-9 | PC 16:1;0_20:4;0 | rs6587148 | 2e-6 | |||||
| YPEL2 | 17 | 11 | rs149807191 | 2e-9 | PC O-16:0;0/20:4;0 | rs149807191 | 7e-8 | |||||
| ABHD3 | 18 | 2 | rs181026394 | 5e-38 | PC 14:0;0_18:2;0 | rs181026394 | 7e-20 | X | ||||
| SMUG1P1 | 18 | 2 | rs1540037 | 1e-15 | PI 18:1;0_18:1;0 | rs1540037 | 8e-17 | X | X | X | X | |
| CERS4 | 19 | 8 | rs2336171 | 2e-189 | SM 38:2;2 | rs2336171 | 6e-53 | X | X | X | X | X |
| TM6SF2 | 19 | 8 | rs190121281 | 3e-24 | TAG 56:6;0 | rs189452885 | 2e-15 | X | X | X | X | |
| APOE | 19 | 8 | rs7412 | 2e-65 | CE 18:2;0 | rs7412 | 8e-36 | X | X | X | X | X |
| SPHK2 | 19 | 8 | rs61751862 | 6e-16 | SM 34:2;2 | rs61751862 | 1e-7 | X | ||||
| TMC4 | 19 | 2 | rs8736 | 2e-301 | PI 18:0;0_18:2;0 | rs8736 | 5e-107 | X | X | |||
| LINC01722 | 20 | 8 | rs438568 | 1e-135 | Cer 42:2;2 | rs364585 | 7e-52 | X | X | X | ||
| NINL | 20 | 3 | rs6037125 | 6e-12 | CE 20:3;0 | rs6037125 | 2e-6 | X | X | X | ||
| HNF4A | 20 | 2 | rs1800961 | 1e-10 | CE 18:3;0 | rs1800961 | 1e-10 | X | X | X | ||
| AGPAT3 | 21 | 3 | rs62229686 | 7e-17 | PC 16:0;0_22:5;0 | rs62229686 | 5e-9 | |||||
| PNPLA3 | 22 | 1 | rs2294915 | 3e-9 | TAG 56:6;0 | rs738409 | 6e-19 | X | X | X | X | X |
Loci found by previous studies for standard lipids or lipid species are marked with an X. Loci are listed as italic gene names. Novel loci are bolded. Two-sided P-values calculated using a linear-mixed-model (uv) and canonical correlation analysis (mv) are reported.
mv multivariate, uv univariate, mv trait cluster number, uv trait lipid species, lead variant rsid, minP minimum of P-values of mv or uv GWAS, LS lipid species.