Table 2.
Novel loci reaching the Bonferroni-corrected significance level
| Locus | Trait | Chrom | Lead variant | P-value | Function | MAF | Finnish enrichm. |
|---|---|---|---|---|---|---|---|
| DTL | cluster 5 (PC 18:0;0_18:2;0) | 1 | rs116329252-A | 4e-11 | intron | 0.04 | 0.87 |
| STK39 | cluster 8 (SM 34:2;2) | 2 | rs143928330-G | 3e-10 | intergenic | 0.03 | 2.94 |
| CDS1 | cluster 2 (PI 16:0;0_18:2;0) | 4 | rs191460656-T | 2e-9 | intron | 0.07 | 68.87 |
| AGPAT2 |
PC 16:0;0_22:5;0 cluster 3 (PC 16:0;0_22:5;0, PC 16:0;0_22:4;0, PC 18:0;0_22:5;0) |
9 | rs2236514-C |
4e-12 2e-12 |
intron | 0.35 | 1.00 |
| SGPL1 |
Cer 42:2;2 cluster 8 (Cer 42:2;2,SM 34:2;2) |
10 | rs12763964-C |
2e-10 6e-17 |
intron | 0.21 | 0.86 |
| KCNJ12 | cluster 7 (PC 16:1;0_20:4;0) | 17 | rs6587148-C | 2e-9 | intron | 0.38 | 0.99 |
| YPEL2 | cluster 11 (PC O-16:0;0/20:4;0) | 17 | rs149807191-T | 2e-9 | intron | 0.06 | 1.42 |
| AGPAT3 |
cluster 3 (PC 16:0;0_22:5;0, PC 18:0;0_22:5;0) |
21 | rs62229686-T | 7e-17 | missense | 0.04 | 1.44 |
Locus locus name identical to gene name from VEP in italic, trait lipid species or multivariate cluster (driver trait from metaPhat analysis), lead variant rsid-minor allele, function variant function from VEP, Finnish enrichm. Finnish enrichment calculated as ratio of minor-allele frequencies between our Finnish data and non-Finnish-non-Swedish-non-Estonian European samples in gnomAD v2.1. Bolded if >2. Two-sided P-values calculated using a linear-mixed-model (uv) and canonical correlation analysis (mv) are reported.