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. 2023 Jun 16;44(11):2184–2200. doi: 10.1038/s41401-023-01107-5

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 5 — Ppara^fl/fl and Ppara^ΔCM mice were administered PBS or LPS (5 mg/kg) for 12 h. a PCA performed using DESeq2 rlog-normalized RNA-seq data. Loadings for principal components (PC) 1, PC2 and PC3 are shown in graph on x-, y- and z-axis. b Venn diagrams showing the number of twofold upregulated (top panel) and two-fold downregulated (bottom panel) genes and their overlap in hearts of Ppara^fl/fl and Ppara^ΔCM mice after PBS or LPS treatment. c Volcano Plot showing the upregulated and downregulated genes in heart tissue from Ppara^ΔCM mice compared with Ppara^fl/fl mice after LPS treatment. d Selected enrichment of GO term analysis of upregulated or downregulated genes in hearts of LPS-treated Ppara^ΔCM mice compared with Ppara^fl/fl mice. e Heatmap of normalized expression values of genes involved in fatty acid metabolism in hearts of Ppara^fl/fl and Ppara^ΔCM mice after PBS or LPS treatment.