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. 2023 Oct 2;55(10):2147–2161. doi: 10.1038/s12276-023-01101-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The structure of tilted T-shaped IR complexed with three human–venom insulin hybrids (PDB ID: 7PG3) a with two insulin molecules (PDB ID: 7STK). b The cryo-EM structure of T-shaped IR bound to two insulin molecules (PDB ID: 8GUY) and c with three insulin molecules (PDB ID: 6SOF). d Insulin and insulin analogs are pink.