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. 2023 Oct 31;9:55. doi: 10.1038/s41540-023-00316-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — FLI1 is the major hub with about 14 connections on average in the found MDSTs. The other hubs are ASCL1, MITF, and MYC with relatively high connectedness on average. We note that MYC emerges as a hub after data integration, which was not the case with the pure structural analysis in Fig. 3.