Fig. 5. SCLC subtype transition from NON-NE to NE subtype.

The network was initially set to NON-NE subtype attractor. After running several asynchronous iterations by keeping the FLI1–ASCL1–MITF pathway active, the system converges to an NE subtype attractor shown in the last iteration. Running further iterations does not move the network to another state. This pathway was identified based on the hubs observed from both unbiased and data-driven network structure analyses. The details of network simulation are provided in Methods Section SCLC TF network subtype transition simulations. The red color means TF is ON and cream color means TF is OFF.