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. 2014 Mar 26;2014(3):CD008486. doi: 10.1002/14651858.CD008486.pub2

Summary of findings 7. Manometry biofeedback versus standard care for chronic constipation.

Manometry biofeedback versus standard care for chronic constipation
Patient or population: Patients with pelvic floor dyssynergia and chronic constipation
 Settings: Outpatient procedure
 Intervention: Manometry biofeedback versus standard care
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of Participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Control Manometry biofeedback versus standard care
Complete spontaneous bowel movements per week at three months The mean number of complete spontaneous bowel movements per week in the control group at three months was 1.9 The mean number of complete spontaneous bowel movements in the intervention group was 2.7 movements higher (1.99 to 3.41 higher)   52
(1 study)
⊕⊕⊝⊝
 low1,2  
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: Confidence interval; RR: Risk ratio; MD: Mean difference
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.

1 High risk of bias in the included study due to open‐label design.
 2 Sparse data (52 patients).