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. 2023 Aug 16;29(21):4492–4503. doi: 10.1158/1078-0432.CCR-23-0290

Figure 1.

Figure 1. Characterization of brain metastasis PDX models. A, Oncoprint of DNA damage repair genomic alterations found in PDXs and their original PT. The three PDX models and their original PT were previously characterized by whole-exome sequencing. Genetic alterations across 126 DDR genes in various repair pathways were identified in the PT and PDX. Only genes with alterations are shown in the figure. B, H&E staining of PDX tumors implanted subcutaneously into the flank and by intracardiac injection into the brain, along with the PT. Tumor histology was consistent in PDX models implanted in the flank, brain and PT. Scale bar represents 100 μm.

Characterization of brain metastasis PDX models. A, Oncoprint of DNA damage repair genomic alterations found in PDXs and their original PT. The three PDX models and their original PT were previously characterized by whole-exome sequencing. Genetic alterations across 126 DDR genes in various repair pathways were identified in the PT and PDX. Only genes with alterations are shown in the figure. B, H&E staining of PDX tumors implanted subcutaneously into the flank and by intracardiac injection into the brain, along with the PT. Tumor histology was consistent in PDX models implanted in the flank, brain and PT. Scale bar represents 100 μm.