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. 2023 Oct 27;15:1183–1196. doi: 10.2147/CMAR.S404371

Table 1.

Published Studies on Relapsed Synovial Sarcoma in Pediatric Age

Author/Series Type of Relapse Treatment at Relapse Outcome
Ferrari et al, 20122 - Italian AIEOP-STSC
Retrospective national, multi-center study (period: 1979–2006)
Number of cases: 44 (initially non-metastatic)
Age < 21 years		 15 local relapse, 22 metastatic, 7 both median time to relapse 20 months 50% had chemotherapy (5 cases had ifosfamide-doxorubicin, 5 high-dose ifosfamide, 5 carboplatin-etoposide, 3 cisplatin-based regimens, 3 dacarbazine); 61% had surgery; 25% had radiotherapy 5-year and 10-year OS 30% and 21%; the most significant factors associated with survival were the time to relapse and the type of recurrence: pts with local and late relapse had 10-year OS of 68.6%
Soole et al, 20144 - French SFCE
Retrospective national, multi-center study (period: 1988–2008)
Number of cases: 37 (initially non-metastatic)
Age 3–18 years, median 12		 27 local relapse, 10 metastatic
median time to relapse 24 months		 75% had surgery; 73% had chemotherapy
(49% ifosfamide-based regimen); 49% had radiotherapy		 5-year EFS 33%, 5-year OS 42%; primary extremity tumor, age less than 12 years and local relapse were associated with relatively better outcome
Scheer et al, 201659 - German CWS
Retrospective national, multi-center study (period: 1981–2010)
Number of cases: 52 (initially non-metastatic)
Age 1–21 years, median 14		 22 local relapse, 24 metastatic, 6 both median time to relapse 2.5 years 62% had chemotherapy; 69% had surgery; 21% had radiotherapy 5-year EFS 26%, 5-year OS 46%; prognostic factors: surgery feasibility, local relapse

Abbreviations: pts, patients; OS, overall survival; EFS, event-free survival; AIEOP-STSC, Associazione italiana ematologia oncologia pediatrica - soft tissue sarcoma committee (Italian Cooperative Group); SFCE, Société Française des Cancers et des leucémies de l’Enfant et de l’adolescent (French pediatric hematology oncology society); CWS, Cooperative weichteilsarkomen studiengruppe (German soft tissue sarcoma cooperative group).