Fig. 1.

The main cells in TME. The stromal cells are closely related to fibroblasts and vascular endothelial cells, pericytes and platelets related to vascular composition, which are the main part of TME. Some cytokines such as TNF, VEGF and chemokines such as CXCL12, CCL27 also play a role in information transmission and energy transfer in TME. As the star component of TME, immune cells can be divided into two opposing categories: ones that inhibit tumor growth and the others that support tumor escape and invasion. The immune cells that inhibit tumor growth mainly refer to M1-type TAMs, tumor-associated Neutrophils (TANs)- N1 type, natural killer cells, B cells and T cells. The large number of immune cells that support tumor cell escape remains divided into many types, such as CAFs, M2-type TAMs, MDSCs, and regulatory cells (Treg) and tolerant DCs.