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. 2023 Oct 24;97:104846. doi: 10.1016/j.ebiom.2023.104846

Supplementary Figure S6.

Supplementary Figure S6

The different characteristics of HPV infection in CSCC and CAde. (a-b) t-SNE plots showed the 10 cell types and their corresponding HPV infection status. (c) The bar plot displayed the ratio of HPV-positive (HPV+) in each cell type. (d) Box plots displayed the estimated stemness scores of cancer cells with different HPV infection statues in CSCC and CAde. ∗∗∗∗P < 0.0001. The P-values were calculated by Wilcoxon Rank Sum Test. (e) t-SNE plot depicted the distribution of HPV+ cancer cells in eight individual samples. (f) Dot plots displayed the expression profiles of HPV-related genes in eight CC samples. (g) Heatmap depicted the z-score of hallmark pathways in cancer cells with different HPV infection statues. (h) Scatter plots displayed the enrichment scores (NES) of enriched terms in CSCC and CAde. The blue dots represented the significant enrichment terms (MSigDB_C5_BP, P-value < 0.05), while the grey dots represented no significance. The label colors corresponded to the specific enrichments of HPV+ status in CSCC and CAde (red), HPV- status (blue) in CSCC and CAde, and HPV+ status in CAde (green).