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. 2023 Oct 24;97:104846. doi: 10.1016/j.ebiom.2023.104846

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© 2023 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 6 — Specific communication patterns between malignant cells and fibroblasts in CSCC and CAde. (a–b) The landscape of cell communications among major cell types in CAde and CSCC, respectively. The color of lines represented major cell types. (c) Bar plot displayed the number of significant interactions among the major cell types of CSCC and CAde. (d) Venn plot displayed the numbers of specific interactions in CSCC and CAde. (e) Hierarchical diagram displayed the communication possibility of selected interaction pairs among source cells and target cells in CSCC and CAde. (f) Bubble plots displayed the communication probability of selected interaction pairs between cancer cells and fibroblasts in CSCC and CAde. (g) Heatmap displayed the expression levels of specific receptors and ligands in cancer cells and identified CAFs. (h) The expression ratios of NRG1-ERBB2 interaction in cancer cells and CAFs. (i) The expression ratios of FN1-ITGA3 interaction in cancer cells and CAFs.