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. 2023 Aug 8;13(11):2412–2431. doi: 10.1158/2159-8290.CD-23-0669

Figure 5.

Figure 5. PRMT5-mediated SDMA modification in MTAP del patient tumor biopsies is extinguished following daily oral administration of 200 mg MRTX1719. Pretreatment and C2D1 tumor biopsies were stained for MTAP and SDMA protein expression by IHC. Adjacent slides were also stained with hematoxylin and eosin (H&E). MTAP and SDMA H-scores were determined by a pathologist and scored in Supplementary Fig. S7A.

PRMT5-mediated SDMA modification in MTAP del patient tumor biopsies is extinguished following daily oral administration of 200 mg MRTX1719. Pretreatment and C2D1 tumor biopsies were stained for MTAP and SDMA protein expression by IHC. Adjacent slides were also stained with hematoxylin and eosin (H&E). MTAP and SDMA H-scores were determined by a pathologist and scored in Supplementary Fig. S7A.