Fig. 3.

A, Superimposition of the succinated Cys178 (2SCys178) form of human DLST (hDLST) in orange and the unmodified hDLST in blue. Red, green, and purple colors in the unmodified form indicate the secondary structural elements that form the two substrate channels. B, The catalytic center of hDLST and its immediate spatial vicinity in the succinated (2SCys178) form, showing the degree of displacement relative to the unmodified structure. Blue color represents displacement <0.5 Å and purple indicates displacement >6.5 Å. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)