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. 2023 May 8;3(4):100328. doi: 10.1016/j.xops.2023.100328

Figure 9.

Figure 9

Full-field stimulus testing (FST) and pupillometry can be used complementary to visual acuity (VA) and OCT observations to more precisely estimate pathological stage. As photoreceptors degenerate, FST threshold increases. We used a red–blue FST of > 10 decibels (dB) as a reference point, indicating advanced rod loss. According to our analysis in Figure 6A, this is equivalent to a blue FST of < −10 dB. The loss of photoreceptor cells in the central macula as well as the peripheral area leads to > 15 dB FST test results and the loss of pupillary cone response. Further degeneration and loss of retinal inner cells result in a decrease in pupillary melanopsin responses.