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. Author manuscript; available in PMC: 2024 Oct 9.
Published in final edited form as: Cancer Cell. 2023 Sep 21;41(10):1803–1816.e8. doi: 10.1016/j.ccell.2023.08.013

Figure 6. ZNF683 directly regulates key pathways of T cell activation and function.

Figure 6.

(A) Schema showing doxycycline-inducible expression of ZNF683 in Jurkat cells.

(B) Volcano plot showing genes differentially regulated by ZNF683 induction by RNA-seq.

(C) CUT&RUN on Jurkat cell lines (top) shows binding of ZNF683 at regions surrounding key immune genes that correspond to differential ATAC-seq peaks in T cell subsets33 and prior PRDM1 ChIP-seq data30. N, Naïve; CM, Central memory, PD-1high, PD-1 high tumor infiltrating CD8 T cells.

(D) Top pathways predicted to be differentially regulated by ZNF683 through CISTROME-GO analysis.

(E) Top predicted motifs for ZNF683 (top) compared to reference PRDM1 motif30 (below).