Table 4.
Mediation analysis of the relationship between OBS and NAFLD.
| Direct effect (average) | Value of p | Mediation effect (average) | Value of p | Proportion-mediated (average) | p-value | |
|---|---|---|---|---|---|---|
| Separate mediators | ||||||
| Neutrophils | −0.116 (−0.133, −0.099) | <0.0001 | −0.012 (−0.015, −0.009) | <0.0001 | 0.093 (0.066, 0.126) | <0.0001 |
| ALT | −0.1120 (−0.141, −0.094) | <0.0001 | −0.001 (−0.005, 0.003) | 0.5740 | 0.009 (−0.024, 0.049) | 0.5740 |
| AST | −0.129 (−0.150, −0.106) | 0.0060 | 0.002 (−0.0001, 0.008) | 0.0540 | −0.017 (−0.064, 0.004) | NA |
| Albumin | −0.117 (−0.134, −0.100) | <0.0001 | −0.010 (−0.012, −0.007) | <0.0001 | 0.076 (0.054, 0.102) | <0.0001 |
| GGT | −0.109 (−0.125, −0.090) | <0.0001 | −0.017 (−0.025, −0.010) | <0.0001 | 0.133 (0.080, 0.197) | <0.0001 |
| UA | −0.111 (−0.127, −0.094) | <0.0001 | −0.018 (−0.022, −0.014) | <0.0001 | 0.139 (0.109, 0.177) | <0.0001 |
| Bilirubin | −0.121 (−0.139, −0.103) | <0.0001 | −0.006 (−0.009, −0.004) | <0.0001 | 0.0503 (0.032, 0.073) | <0.0001 |
| TG | −0.111 (−0.129, −0.091) | <0.0001 | −0.018 (−0.024, −0.009) | <0.0001 | 0.138 (0.071, 0.184) | <0.0001 |
| TC | −0.127 (−0.143, −0.109) | <0.0001 | −0.001 (−0.002, −0.0002) | 0.0120 | 0.009 (0.002, 0.017) | 0.0120 |
| HDL-cholesterol | −0.091 (−0.107, −0.075) | <0.0001 | −0.038 (−0.044, −0.032) | <0.0001 | 0.293 (0.246, 0.351) | <0.0001 |
| Fasting glucose | −0.120 (−0.137, −0.101) | <0.0001 | −0.005 (−0.008, −0.001) | <0.0001 | 0.036 (0.015, 0.069) | <0.0001 |
OBS, oxidative balance score; NAFLD, nonalcoholic fatty liver disease; NA, not available; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma glutamyltransferase; UA, uric acid; TG, triglycerides; TC, total cholesterol; HDL, high-density lipoprotein.