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. 2023 Oct 29;10(2):e001010. doi: 10.1136/lupus-2023-001010

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Correlation between kidney p16^Ink4a staining, renal disease parameters and kidney CD8⁺ T cell infiltration and fibrosis in aged B6.Sle1.2.3 mice. Correlation between p16^Ink4a staining (positive cells/mm²) on FFPE kidney sections of 13 B6.Sle1.2.3 mice of 9–11 months of age, and (A) urine albumin/creatinine ratio (mg/g), (B,C) activity and chronicity scores (median from three blinded scorers, total scale: 0–12), (D) glomerular IgG deposit score (mean scores from three blinded scorers, 30 glomeruli/mouse), (E) CD8⁺ T cell kidney infiltration (positive cells/mm²) and (F) renal fibrosis (semi-quantitative PSR staining scores, scale from 0 to 6). r and p values: Spearman’s rank-order correlation coefficient. B6.Sle1.2.3, B6.NZMSle1/Sle2/Sle3; FFPE, formalin-fixed paraffin-embedded; PSR, Picrosirius red.