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. 2023 Oct 29;10(2):e001010. doi: 10.1136/lupus-2023-001010

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Disease parameters, kidney p16^Ink4a, CD8⁺ T cell infiltration and fibrosis over time. Two B6, 7 to 8 B6.Sle1.2.3 mice per time point. (A,B) Total IgG (μg/mL) and anti-dsDNA antibody (U/mL) in plasma. (C) Semi-quantitative evaluation of glomerular IgG deposits in frozen OCT kidney sections. (D) Urine albumin/creatinine ratio (mg/g). (E,F) Histopathological activity and chronicity scores on H&E-stained FFPE kidney sections (scale: 0–12). (G–I) Quantification of p16^Ink4a (positive cells/mm²), quantification of anti-CD8 staining (positive cells/mm²), semi-quantitative PSR staining scores (scale: 0–6) on serial FFPE kidney sections. Bars: mean±SD. Green: B6; maroon: B6.Sle1.2.3. Circles: female; squares: male. Horizontal dotted lines: mean plus 2 SD of all 12 (2–12 month old) B6 mice. anti-dsDNA, anti-double-stranded DNA; B6.Sle1.2.3, B6.NZMSle1/Sle2/Sle3; FFPE, formalin-fixed paraffin-embedded; OCT, optimal cutting temperature; PSR, Picrosirius red.