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. 2023 Oct 29;10(2):e001010. doi: 10.1136/lupus-2023-001010

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Association of p16^Ink4a staining with renal disease in a second (ageing) cohort: 8–12 month-old mice (6 B6, 23 B6.Sle1.2.3 mice). (A–C) Renal disease parameters: urine albumin/creatinine ratio (mg/g), histopathological activity and chronicity scores on H&E-stained FFPE kidney sections (scale: 0–12). (D,E) Quantification of anti-CD8 staining (positive cells/mm²) and semi-quantitative PSR staining scores (scale: 0–6) on serial FFPE kidney sections (with p16^Ink4a). (F) Semiquantitative evaluation of glomerular IgG deposits in frozen OCT kidney sections. (G,H) Systemic disease parameters: total IgG (μg/mL) and anti-dsDNA antibody (U/mL) in plasma. Horizontal bars: medians. p values: Kruskal-Wallis and Dunn’s post-hoc tests. ≤Q2: p16^Ink4a-low (≤50th percentile), >Q2: p16^Ink4a-high (>50th percentile) B6.Sle1.2.3 kidneys. anti-dsDNA, anti-double-stranded DNA; B6.Sle1.2.3, B6.NZMSle1/Sle2/Sle3; FFPE, formalin-fixed paraffin-embedded; OCT, optimal cutting temperature; PSR, Picrosirius red.