Table 3.
Sensitivity and specificity of the electrical impedance spectroscopy cohort (EIS) and the reference cohort by cytology, TZ type and age group in identifying CIN2+, with corresponding risk ratios (RR) of sensitivity and specificity
| EIS | Reference | Sensitivity | EIS | Reference | Specificity | P value | ||
| Sensitivity | Sensitivity | RR (95%)* | P value | Specificity | Specificity | RR (95%)* | ||
| All | 94 (90–97) | 68 (63–73) | 1.38 (1.28 to 1.49) | <0.0001 | 34 (29–39) | 84 (81–87) | 0.40 (0.35 to 0.46) | <0.0001 |
| ASC-US | 94 (70–100) | 56 (21–86) | 1.69 (0.93 to 3.07) | 0.0219 | 47 (36–59) | 97 (91–99) | 0.49 (0.39 to 0.62) | <0.0001 |
| LSIL | 77 (61–89) | 43 (31–55) | 1.79 (1.30 to 2.45) | 0.0006 | 42 (35–49) | 92 (89–95) | 0.45 (0.38 to 0.53) | <0.0001 |
| ASC-H | 99 (94–100) | 63 (54–71) | 1.57 (1.38 to 1.78) | <0.0001 | 11 (6–19) | 65 (54–74) | 0.17 (0.10 to 0.30) | <0.0001 |
| HSIL | 100 (95–100) | 86 (80–91) | 1.16 (1.09 to 1.23) | 0.0007 | 6 (0–29) | 46 (31–61) | 0.13 (0.02 to 0.89) | 0.0033 |
| AGC-NOS | 67 (9–99) | 60 (15–95) | 1.11 (0.38 to 3.25) | 0.8504 | 44 (24–65) | 96 (78–100) | 0.46 (0.29 to 0.72) | 0.0001 |
| AGC-FN | 50 (1–99) | 62 (32–86) | 0.81 (0.19 to 3.47) | 0.7565 | 100 (3–100) | 25 (1–81) | 4.0 (0.73 to 21.84) | 0.1709 |
| TZ1 | 94 (89–97) | 67 (61–73) | 1.40 (1.27 to 1.53) | <0.0001 | 31 (26–37) | 84 (80–88) | 0.37 (0.31 to 0.44) | <0.0001 |
| TZ2 | 95 (87–99) | 71 (62–80) | 1.34 (1.18 to 1.52) | 0.0001 | 40 (32–49) | 84 (79–88) | 0.48 (0.38 to 0.59) | <0.0001 |
| <30 years | 93 (84–98) | 72 (63–79) | 1.30 (1.15 to 1.48) | 0.0007 | 35 (26–44) | 77 (70–83) | 0.45 (0.35 to 0.59) | <0.0001 |
| 30–44 years | 95 (89–98) | 68 (62–75) | 1.39 (1.25 to 1.53) | <0.0001 | 33 (27–40) | 86 (81–90) | 0.39 (0.32 to 0.47) | <0.0001 |
| ≥45 y | 94 (79–99) | 59 (43–73) | 1.59 (1.23 to 2.07) | 0.0008 | 35 (24–47) | 89 (82–94) | 0.39 (0.28 to 0.54) | <0.0001 |
| HG cytology | 99 (96–100) | 75 (70–80) | 1.32 (1.24 to 1.41) | <0.0001 | 11 (6–18) | 58 (49–66) | 0.19 (0.12 to 0.32) | <0.0001 |
| LG cytology | 81 (69–90) | 45 (35–57) | 1.79 (1.37 to 2.33) | <0.0001 | 43 (38–49) | 93 (91–96) | 0.46 (0.41 to 0.53) | <0.0001 |
| 1 biopsy | 64 (31–89) | 36 (13–65) | 1.78 (0.77 to 4.10) | 0.1654 | 51 (43–59) | 99 (94–100) | 0.51 (0.44 to 0.60) | <0.0001 |
| 2 biopsies | 90 (81–96) | 59 (49–68) | 1.52 (1.28 to 1.81) | <0.0001 | 23 (17–30) | 90 (86–93) | 0.26 (0.20 to 0.34) | <0.0001 |
| ≥3 biopsies | 100 | 67 (60–74) | 1.49 (1.34 to 1.65) | <0.0001 | 0 | 67 (59–75) | 0 | <0.0001 |
*The values of risk ratio >1 imply better/improved effect with ZedScan.
AGC-FN, atypical glandular cells that favour neoplasia; AGC-NOS, atypical glandular cells not otherwise specified; ASC-H, atypical squamous cells that cannot exclude HSIL; ASC-US, atypical squamous cells of undetermined significance; CIN, cervical intraepithelial neoplasia; EIS, electrical impedance spectroscopy; HG, high grade; HSIL, high-grade squamous intraepithelial lesion; LG, low grade; LSIL, low-grade squamous intraepithelial lesion; TZ, transformation zone.