Table 1.

Eligibility criteria organised in accordance with the population, interventions, comparisons, outcomes, setting and study design reporting structure

Population	Youth aged 6–17 years who are taking antipsychotic medications. Youth most likely to be taking antipsychotic medications include those diagnosed with a neurodevelopmental disorder (ie, intellectual disability, autism spectrum disorder, attention-deficit/hyperactivity disorder, Tourette syndrome) and comorbid disruptive behaviour disorder/behavioural issues or youth with first-episode psychosis, childhood schizophrenia or bipolar mania. Study will be eligible for inclusion if ≥70% of the sample is taking antipsychotic medications.
Interventions	All interventions that incorporate a ‘lifestyle’ intervention component and aim to improve physical health outcomes will be eligible. This includes any educational, psychotherapeutic, social and behavioural intervention that aims to increase exercise or physical activity, optimise dietary intake, aid nicotine cessation or improve sleep quality and duration.
Comparisons	All relevant control interventions will be included (ie, treatment as usual/usual care, placebo, no treatment, waiting list).
Outcomes	Physical health outcomes that will be included: Anthropometric measures, including weight, height, waist circumference or body mass index percentile. Blood pressure. Metabolic or biological markers, including glucose and lipid levels, haemoglobin A1c, C-reactive protein or other relevant blood and serum markers. Presence of cardiovascular or respiratory disease. Physical health behaviour, including physical activity levels, smoking/vaping behaviour, dietary intake, sleep quality and duration, engagement in treatment and attendance. Indicators of physical fitness, including aerobic capacity (ie, maximal oxygen consumption), and muscle strength. Physical health-related quality of life. Side effects of antipsychotics, including adverse drug reactions. Physical health outcomes that will be excluded: motor development.
Setting	All settings will be included: primary and secondary care, hospital (inpatient or outpatient), community and school-based service provisions or remote (digital application-based or telehealth/web health services).
Study design and characteristics	Applicable randomised controlled trials published in the English language will be included. All years will be considered, and no date restrictions will be applied. Pseudorandomised control trials, comparative studies with concurrent controls, case series and cohort studies will be excluded. Conference abstracts, dissertations/theses, papers that are not peer-reviewed and papers published in a language other than English will be excluded.