Table 2.

Eligibility criteria for participants

Inclusion criteria

Adult, male or female, with spasticity of neurological origin (multiple sclerosis, cerebral stroke, traumatic brain injury, etc) and eligible for botulinum toxin injection Able to deliver informed consent to participate in the study Affiliation with a social security system

Exclusion criteria

Medical contraindication to virtual reality (epilepsy, schizophrenia, strabismus, amblyopia, anisometropia), local contraindication of wearing a headset (dermatological lesion of the face or the skull) Any medical condition deemed by the investigator to be incompatible with the research (eg, major cognitive disorders MMSE (Mini Mental State Examination <24/30, impaired vision or hearing) Indication of sedation by Entonox during botulinum toxin injection sessions Every patient who has experienced virtual reality Cardiovascular diagnosis of rhythm perturbances or priorly diagnosed anxiety disorders that may hinder results Pregnant or breastfeeding women