Table 3.

Retinal layer thickness* by quartile of MPOD at CAREDS baseline among eyes without manifest POAG (n=347 participants)

Retinal layer thickness* (μm, mean±SE)	Number of eyes	MPOD-CAREDS baseline, 0.5° (optical density units)				β±SE (1−SD increase)	P-trend
		Quartile 1 (0.00–0.23)	Quartile 2 (0.23–0.38)	Quartile 3 (0.38–0.51)	Quartile 4 (0.51–1.00)
Peripapillary RNFL
Average	631	93.9±1.0	93.6±1.0	92.8±1.0	93.2±0.9	0.3±0.5	0.53
Inferior	631	120.9±1.4	121.2±1.5	120.1±1.6	121.1±1.7	0.2±0.7	0.77
Superior	631	111.6±1.5	110.9±1.4	109.8±1.4	110.9±1.4	0.2±0.8	0.80
Nasal	631	72.3±1.2	72.3±1.2	70.7±1.2	71.2±1.1	0.7±0.6	0.26
Temporal	631	71.4±1.3	70.3±1.3	70.8±1.2	69.7±1.2	0.4±0.6	0.50
Macular RNFL
Central	668	13.2±0.3	12.9±0.2	13.1±0.2	13.7±0.2	0.2±0.1	0.13
Inner	668	23.9±0.3	23.5±0.3	23.5±0.2	23.6±0.2	0.1±0.1	0.53
Outer	666	40.1±0.6	39.1±0.5	39.7±0.5	39.6±0.5	0.0±0.3	0.88
Macular GCL
Central	667	15.7±0.5	15.6±0.5	16.2±0.3	17.2±0.4	0.5±0.2	0.01
Inner	668	46.0±0.5	46.0±0.5	46.3±0.5	46.6±0.4	0.3±0.2	0.26
Outer	665	30.2±0.3	30.1±0.3	30.5±0.3	30.3±0.3	0.1±0.1	0.38
Macular IPL
Central	669	20.9±0.4	20.8±0.3	21.4±0.3	22.4±0.3	0.6±0.2	<0.001
Inner	669	38.0±0.3	38.0±0.3	38.1±0.3	38.4±0.2	0.2±0.1	0.23
Outer	668	25.4±0.2	25.5±0.2	25.6±0.2	25.7±0.2	0.1±0.1	0.15
Macular GCC
Central	656	49.2±1.0	48.9±1.0	50.6±0.8	53.1±0.8	1.3±0.4	0.003
Inner	657	107.6±0.9	107.4±1.0	107.8±1.0	108.5±0.7	0.4±0.4	0.35
Outer	655	95.5±0.8	94.7±0.9	95.6±1.0	95.6±0.8	0.3±0.4	0.50

*Adjusted for age and axial length.

CAREDS, Carotenoids in Age-Related Eye Disease Study; GCC, ganglion cell complex; GCL, ganglion cell layer; IPL, inner plexiform layer; MPOD, macular pigment optical density; POAG, primary open-angle glaucoma; RNFL, retinal nerve fibre layer.